A meta-analysis of the relative risk of mortality for type 1 diabetes patients compared to the general population: Exploring temporal changes in relative mortality

TWC Lung; AJ Hayes; WH Herman; L Si; AJ Palmer; PM Clarke

Journal article

A meta-analysis of the relative risk of mortality for type 1 diabetes patients compared to the general population: Exploring temporal changes in relative mortality

TWC Lung, AJ Hayes, WH Herman, L Si, AJ Palmer, PM Clarke

Plos One | Published : 2014

DOI: 10.1371/journal.pone.0113635

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Abstract

Aims: Type 1 diabetes has been associated with an elevated relative risk (RR) of mortality compared to the general population. To review published studies on the RR of mortality of Type 1 diabetes patients compared to the general population, we conducted a meta-analysis and examined the temporal changes in the RR of mortality over time.Methods: Systematic review of studies reporting RR of mortality for Type 1 diabetes compared to the general population. We conducted meta-analyses using a DerSimonian and Laird random effects model to obtain the average effect and the distribution of RR estimates. Sub-group meta-analyses and multivariate metaregression analysis was performed to examine heterog..

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University of Melbourne Researchers

Philip Clarke Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

PMC was funded from an Australian NHMRC Career Development Award (571122) and partially funded from the NHMRC project grant (1028335). TWCL was partially funded from the NHMRC Capacity Building Grant (571372) and the NHMRC project grant (1028335). AJH was supported by NHMRC Capacity Building Grant (571372). AJP and WHH were partially supported by an Australian NHMRC project grant (1028335). WHH was supported by grant numbers P60DK020572 (MDRTC) and P30DK092926 (MCDTR) both from the National Institute of Diabetes and Digestive and Kidney Diseases. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.